A working way out of the list, honoured quickly. A real postal address in the message. A subject line that does not lie about what is inside.
In Europe there is more. The recipient has a right to know where the address came from and what happens to it, whether or not they ever asked. That is a notice you have to actually publish, not a checkbox.
And the volume itself is part of the argument. A capped number of messages to a named business role is defensible. An unbounded sequence to a personal address is not.
How we do it
Opt-out is actioned the same business day, permanently, across every campaign and every client. The exclusion list you give us is applied before the first send.